美中彩票

發布者:群體微生物研究中心發布時間:2019-09-10浏覽次數:10

特邀學術報告

  

 

時間:2019911 上午1000

地點:资环楼105 室(芭田報告廳)

報告人:高永貴 教授

報告題目:Action mechanism of antimicrobial and

 the bacterial resistance

主持人:張煉輝 教授

  

 

報告人簡介

高永貴博士,新加坡國立研究基金獲得者,現爲南洋理工大學生物科學學院Tenured副教授和新加坡科技研究局細胞分子研究所資深研究員, 專長爲結構生物學和蛋白質化學。研究領域爲核糖體的結構、功能,以核糖體爲靶位的抗生素的作用機理及新型藥物設計;以及RNA修飾所引發的基因調控和其關聯的疾病(如肥胖基因FTO)的機理和拮抗劑的研制、細胞分泌多糖的生物學合成和利用開發等。已在Science, Cell, Nature Structural & Molecular BiologyPNAS等雜志上發表文章, 其中多篇論文被雜志封面所強調, 包括Science, Cell, JBC, Chemical Sciences等。目前擔任Scientific Reports 等雜志的編委。

  

 

報告摘要

Current antimicrobial resistance crisis urgently requires a better understanding of drug resistance mechanisms and effectively targeted drug discovery. A wide range of mechanisms could mediate antibiotic resistance, which is currently one of the biggest threats to global health and food security. We have determined several structures of ribosome complexes that offers insight into action mechanism of antibiotic as well as rationalizes mutations resulting in resistance. In particular, the newly emerged ATP-binding cassette family proteins (ABC-F) can confer resistance across species to various antibiotic classes through unknown mechanisms.  Elucidating these mechanisms will enable us to rational design improved antimicrobial agents that overcome multidrug-resistant bacteria. On the other hand, antibiotics could help us trap ribosome in certain state so that the structure can be reconstructed and visualized. In this talk, I will be presenting our recent progress towards a better understanding of action mechanisms of antibiotic and drug resistance involving ribosome protection, protein translation and regulation. 

  

  

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華南農業大學群體微生物研究中心

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